Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice

Department of Oncology, First Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 310006, China. cpf12345@163.com

OBJECTIVE: To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma. METHODS: B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively. RESULTS: The high-, medium-, and low-doses of the extracts and the interferon-alpha (IFN-alpha) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the normal saline (NS)-treated group (P<0.05>

PMID: 16965745 [PubMed - indexed for MEDLINE]

Studies on the accelerated solvent extraction of Panax notoginseng saponins

English Title: Studies on the accelerated solvent extraction of Panax notoginseng saponins.Personal Authors: Li Peng, Wan JianBo, Li ShaoPing, Wang YiTao Author Affiliation: Institute of Chinese Medical Sciences, University of Macau, Macau, China.Editors: No editorsDocument Title: Chinese Journal of Natural Medicines, 2004 (Vol. 2) (No. 3) 157-161 Abstract:
Studies were conducted to apply accelerated solvent extraction (ASE) technique to P. notoginseng [P. pseudoginseng var. notoginseng] saponins and to explore the application of this technique in the quality control of Chinese herbs. Investigations of single factors were performed to optimize the factors that affect the efficiency of ASE by using the contents of saponins, ginsenoside Rb1 and ginsenoside Rg1 as quantitative markers. The best conditions for ASE extraction of P. notoginseng saponins were obtained as follows: methanol as solvent, particle size between 0.3 and 0.45 mm, 150°C temperature, pressure under 6.895 MPa, 15-minute duration, and single extraction. ASE technique can be used to extract P. notoginseng saponins quickly and effectively.Publisher: Chinese Journal of Natural Medicines